{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:49:28Z","timestamp":1788670168387,"version":"build-2803163510"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,10,27]]},"abstract":"<jats:p>\n            The magnitude of the morbidity and mortality inflicted upon the global population in less than 1 year has driven the inescapable conclusion that the discovery and development of effective antiviral drugs for COVID-19 are urgent and should be prioritized. The antiviral drug discovery programs that emerged for HIV and hepatitis C virus have enabled technology and expertise to accelerate this process for SARS-CoV-2. The description of candidate lead inhibitors for the viral main protease (M\n            <jats:sup>pro<\/jats:sup>\n            ) exemplifies this accelerated approach and reminds us of the needs and opportunities for addressing this pandemic.\n          <\/jats:p>","DOI":"10.1128\/mbio.02134-20","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T14:26:19Z","timestamp":1601303179000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Antiviral Drug Discovery To Address the COVID-19 Pandemic"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0962-9254","authenticated-orcid":false,"given":"Douglas D.","family":"Richman","sequence":"first","affiliation":[{"name":"University of California San Diego, Distinguished Professor of Pathology and Medicine (Active Emeritus), Director, The HIV Institute, Co-Director, San Diego Center for AIDS Research, Florence Seeley Riford Chair in AIDS Research (Emeritus), La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01833-20"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb4489"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb5883"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01201-19"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Good S Westover J Jung KH La Colla P Collu G Moussa A Canard B Sommadossi J-P. 2020. 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