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However, SA binding preference does not fully account for the complexities of influenza A virus transmission in humans. Our previous findings reveal that viruses that are known to bind \u03b12,6-SA\n                    <jats:italic>in vitro<\/jats:italic>\n                    have different transmission kinetics\n                    <jats:italic>in vivo<\/jats:italic>\n                    , suggesting that diverse SA interactions may occur during their life cycle. In this study, we examine the role of host SA on viral replication, shedding, and transmission\n                    <jats:italic>in vivo<\/jats:italic>\n                    . We highlight the critical role of SA presence during virus shedding, such that attachment to SA during virion egress is equally important as detachment from SA during virion release. These insights support the potential of broadly acting neuraminidases as therapeutic agents capable of restraining viral transmission\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Our study unveils intricate virus-host interactions during shedding, highlighting the necessity to develop innovative strategies to effectively target transmission.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02203-23","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T09:01:13Z","timestamp":1704963673000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Inhibiting influenza virus transmission using a broadly acting neuraminidase that targets host sialic acids in the upper respiratory tract"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9428-1469","authenticated-orcid":true,"given":"Mila B.","family":"Ortigoza","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, New York, USA"},{"name":"Department of Microbiology, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4736-1148","authenticated-orcid":false,"given":"Catherina L.","family":"Mobini","sequence":"additional","affiliation":[{"name":"Department of Microbiology, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2195-1864","authenticated-orcid":false,"given":"Hedy L.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-2681","authenticated-orcid":false,"given":"Stacey","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8668-1270","authenticated-orcid":false,"given":"Cynthia A.","family":"Loomis","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-8090","authenticated-orcid":true,"given":"Jeffrey N.","family":"Weiser","sequence":"additional","affiliation":[{"name":"Department of Microbiology, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)74657-5"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.80.2081.457-a"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.62.4.561"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.39.3.229-241.1940"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.118.2.257"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00859-12"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33354"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604157103"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02359-18"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-009-0476-8"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00815"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/440435a"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02677-05"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.01.011"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-009-9307-3"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136212"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605134103"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.01.002"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00967-13"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.epidem.2015.04.003"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001083"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00624-17"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","unstructured":"Ortigoza MB Blaser SB Zafar MA Hammond AJ Weiser JN. 2018. 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