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There is increasing evidence that bacterial excreted small molecules play a critical role during infection. We have shown that a quorum sensing (QS)-regulated excreted small molecule, 2-AA, which is abundantly produced by\n            <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n            , promotes persistent infections, dampens host inflammation, and triggers mitochondrial dysfunction in skeletal muscle. QS is a cell-to-cell communication system utilized by bacteria to promote collective behaviors. The significance of our study in identifying a mechanism that leads to skeletal muscle dysfunction, via the action of a QS molecule, is that it may open new avenues in the control of muscle loss as a result of infection and sepsis. Given that QS is a common characteristic of prokaryotes, it is possible that 2-AA-like molecules promoting similar effects may exist in other pathogens.\n          <\/jats:p>","DOI":"10.1128\/mbio.02211-19","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T14:15:23Z","timestamp":1569852923000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Pseudomonas aeruginosa Quorum Sensing Molecule Alters Skeletal Muscle Protein Homeostasis by Perturbing the Antioxidant Defense System"],"prefix":"10.1128","volume":"10","author":[{"given":"Arunava","family":"Bandyopadhaya","sequence":"first","affiliation":[{"name":"Department of Surgery, Center for Surgery, Innovation and Bioengineering, Massachusetts General Hospital, Harvard Medical School Boston, Massachusetts, USA"},{"name":"Shriners Hospitals for Children Boston, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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