{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T04:17:24Z","timestamp":1793593044476,"version":"4.5.0"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:00:00Z","timestamp":1551139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Fund for Scientific Research Flanders, FWO","award":["1S55817N"],"award-info":[{"award-number":["1S55817N"]}]},{"name":"Fund for Scientific Research Flanders, FWO","award":["3G.0447.18"],"award-info":[{"award-number":["3G.0447.18"]}]},{"name":"Fund for Scientific Research Flanders, FWO","award":["3G.00448.18"],"award-info":[{"award-number":["3G.00448.18"]}]},{"name":"Fund for Scientific Research Flanders, FWO","award":["G.0C49.13N"],"award-info":[{"award-number":["G.0C49.13N"]}]},{"name":"Fund for Scientific Research Flanders, FWO","award":["G.0H7816N"],"award-info":[{"award-number":["G.0H7816N"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,2,26]]},"abstract":"<jats:p>\n            Candidiasis is a potentially lethal condition that is caused by systemic dissemination of\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            , a common fungal commensal residing mostly on mucosal surfaces. The transition of\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            from an innocuous commensal to an opportunistic pathogen goes hand in hand with its morphological transformation from a fungus to a hyphal appearance. On the one hand, the latter manifestation enables\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            to penetrate tissues, while on the other hand, the expression of many hypha-specific genes also endows it with the capacity to trigger particular cytokine responses. The Nlrp3 inflammasome is a crucial component of the innate immune system that provokes release of the IL-1\u03b2 cytokine from myeloid cells upon encountering\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            hyphae. Our study reveals the peptide candidalysin as one of the hypha-derived drivers of Nlrp3 inflammasome responses in primary macrophages and, thus, contributes to better understanding the fungal mechanisms that determine the pathogenicity of\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/mbio.02221-18","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T22:31:10Z","timestamp":1546900270000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":113,"title":["Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae"],"prefix":"10.1128","volume":"10","author":[{"given":"Ona","family":"Rogiers","sequence":"first","affiliation":[{"name":"VIB-KU Leuven Center for Microbiology, Leuven, Belgium"},{"name":"KU Leuven Laboratory of Molecular Cell Biology, 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