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We have postulated the existence in\n            <jats:named-content content-type=\"genus-species\">T. pallidum<\/jats:named-content>\n            of a flavin-dependent acetogenic energy conservation pathway that would generate additional ATP for\n            <jats:named-content content-type=\"genus-species\">T. pallidum<\/jats:named-content>\n            bioenergetics. In the proposed acetogenic pathway, first\n            <jats:sc>d<\/jats:sc>\n            -lactate would be converted to pyruvate. Pyruvate would then be metabolized to acetate in three additional steps, with ATP being generated via substrate-level phosphorylation. This study provides structural, biochemical, and biophysical evidence for the first\n            <jats:named-content content-type=\"genus-species\">T. pallidum<\/jats:named-content>\n            enzyme in the pathway (TP0037;\n            <jats:sc>d<\/jats:sc>\n            -lactate dehydrogenase) requisite for the conversion of\n            <jats:sc>d<\/jats:sc>\n            -lactate to pyruvate. The findings represent the first experimental evidence to support a role for an acetogenic energy conservation pathway that would contribute to nonglycolytic ATP production in\n            <jats:named-content content-type=\"genus-species\">T. pallidum<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/mbio.02249-20","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T17:30:23Z","timestamp":1600709423000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Biophysical and Biochemical Characterization of TP0037, a\n            <scp>d<\/scp>\n            -Lactate Dehydrogenase, Supports an Acetogenic Energy Conservation Pathway in Treponema pallidum"],"prefix":"10.1128","volume":"11","author":[{"given":"Ranjit K.","family":"Deka","sequence":"first","affiliation":[{"name":"Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Z.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Norgard","sequence":"additional","affiliation":[{"name":"Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6563-1338","authenticated-orcid":false,"given":"Chad A.","family":"Brautigam","sequence":"additional","affiliation":[{"name":"Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas, USA"},{"name":"Department of Biophysics, UT Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000149848.03733.c1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","unstructured":"Bremer V Marcus U Hamouda O. 2012. 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