{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:00:27Z","timestamp":1753880427065,"version":"3.41.2"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01AI158615-01, R21AI142708, R41AI142708"],"award-info":[{"award-number":["R01AI158615-01, R21AI142708, R41AI142708"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","award":["Emerging Pathogens Program"],"award-info":[{"award-number":["Emerging Pathogens Program"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            When a female mosquito engorges on a mammalian host, components of the blood meal can affect mosquito fitness and indirectly influence pathogen infectivity. We demonstrate that mammalian adiponectin, ingested during\n            <jats:italic>Anopheles gambiae<\/jats:italic>\n            blood feeding, co-localizes within mosquito midguts and decreases\n            <jats:italic>Plasmodium<\/jats:italic>\n            infection in the vector. Transcriptomic and RNAi studies reveal that the\n            <jats:italic>A. gambiae<\/jats:italic>\n            adiponectin receptor is involved in downregulating lipophorin, a lipid transporter that is important for egg development and\n            <jats:italic>Plasmodium<\/jats:italic>\n            infection in mosquitoes. These studies characterize a cross-phyla interaction between the mammalian host and\n            <jats:italic>A. gambiae<\/jats:italic>\n            that negatively impacts\n            <jats:italic>Plasmodium<\/jats:italic>\n            survival in its arthropod vector.\n          <\/jats:p>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              When a female mosquito takes a blood meal from a mammalian host, components of the blood meal can affect mosquito fitness and indirectly influence pathogen infectivity. We identified a pathway involving an\n              <jats:italic>Anopheles gambiae<\/jats:italic>\n              adiponectin receptor, which, triggered by adiponectin from an incoming blood meal, decreases\n              <jats:italic>Plasmodium<\/jats:italic>\n              infection in the mosquito. Activation of this pathway negatively regulates lipophorin expression, an important lipid transporter that both enhances egg development and\n              <jats:italic>Plasmodium<\/jats:italic>\n              infection. This is an unrecognized cross-phyla interaction between a mosquito and its vertebrate host. These processes are critical to understanding the complex life cycle of mosquitoes and\n              <jats:italic>Plasmodium<\/jats:italic>\n              following a blood meal and may be applicable to other hematophagous arthropods and vector-borne infectious agents.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/mbio.02257-23","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T14:02:04Z","timestamp":1702303324000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Signaling between mammalian adiponectin and a mosquito adiponectin receptor reduces\n            <i>Plasmodium<\/i>\n            transmission"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2241-5541","authenticated-orcid":true,"given":"Yu-Min","family":"Chuang","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases, Department of 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