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The cell wall is an essential organelle that protects fungi from the environment. Chitosan, the deacetylated form of chitin, has been shown to be an essential component of the cryptococcal cell wall during infection of a mammalian host. In this study, we screened a set of 480 compounds, which are known to have defined biological activities, for activity that reduced chitosan production in\n                    <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n                    . Two of these compounds were confirmed using an alternative method of measuring chitosan, and one of these was demonstrated to impact the cAMP signal transduction pathway. This work demonstrates that the cAMP pathway regulates chitosan biosynthesis in\n                    <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n                    and validates that this screening approach could be used to find potential antifungal agents.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02264-19","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T07:54:47Z","timestamp":1576482887000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["The Aminoalkylindole BML-190 Negatively Regulates Chitosan Synthesis via the Cyclic AMP\/Protein Kinase A1 Pathway in Cryptococcus neoformans"],"prefix":"10.1128","volume":"10","author":[{"given":"Brian T.","family":"Maybruck","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woei C.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Specht","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2888-4859","authenticated-orcid":false,"given":"Ma. 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