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While the live attenuated OPV has been the vaccine of choice, a major concern is its ability to revert to a form that can cause paralysis, so-called vaccine-associated paralytic poliomyelitis. Therefore, the new endgame strategy of the Global Polio Eradication Initiative includes the introduction of an IPV. However, the feasibility of the use of current IPV formulations in developing countries is limited, because IPV is insufficiently stable to be purified, transported, and stored under unrefrigerated conditions. We successfully designed the sIPV for use in the dry state that maintains the full vaccine potency in animal models after incubation at ambient temperature. This report provides, for the first time, candidate formulations of sIPV that are stable at elevated temperatures.<\/jats:p>","DOI":"10.1128\/mbio.02287-18","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T10:24:39Z","timestamp":1543227879000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Development of Thermostable Lyophilized Sabin Inactivated Poliovirus Vaccine"],"prefix":"10.1128","volume":"9","author":[{"given":"Woo-Jin","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"Gbormittah","sequence":"additional","affiliation":[{"name":"Integrity Bio Inc., Camarillo, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Chang","sequence":"additional","affiliation":[{"name":"Integrity Bio Inc., Camarillo, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong S.","family":"Chang","sequence":"additional","affiliation":[{"name":"Integrity Bio Inc., Camarillo, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4559-8774","authenticated-orcid":false,"given":"Jae U.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2994218"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/291547a0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402981111"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-8_Part_1-199710150-00010"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400472111"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1955.02960140001001"},{"key":"e_1_3_3_8_2","first-page":"23","article-title":"Immunization with live attenuated poliovirus vaccine","volume":"101","author":"Krugman S","year":"1961","unstructured":"Krugman S, Warren J, Eiger MS, Berman PH, Michaels RM, Sabin AB. 1961. 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