{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:52:21Z","timestamp":1791532341621,"version":"4.3.4"},"reference-count":114,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI134078"],"award-info":[{"award-number":["AI134078"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI047928"],"award-info":[{"award-number":["AI047928"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["NS116716"],"award-info":[{"award-number":["NS116716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["5T32AI0007405-28"],"award-info":[{"award-number":["5T32AI0007405-28"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,12,22]]},"abstract":"<jats:p>\n                    Group B\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    (GBS) asymptomatically colonizes the female reproductive tract but is a common causative agent of meningitis. GBS meningitis is characterized by extensive infiltration of neutrophils carrying high concentrations of calprotectin, a metal chelator. To persist within inflammatory sites and cause invasive disease, GBS must circumvent host starvation attempts. Here, we identified global requirements for GBS survival during calprotectin challenge, including known and putative systems involved in metal ion transport. We characterized the role of zinc import in tolerating calprotectin stress\n                    <jats:italic>in vitro<\/jats:italic>\n                    and in a mouse model of infection. We observed that a global zinc uptake mutant was less virulent than the parental GBS strain and found calprotectin knockout mice to be equally susceptible to infection by wild-type (WT) and mutant strains. These findings suggest that calprotectin production at the site of infection results in a zinc-limited environment and reveals the importance of GBS metal homeostasis to invasive disease.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02302-20","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T09:29:54Z","timestamp":1604914194000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Identification of Zinc-Dependent Mechanisms Used by Group B\n                    <i>Streptococcus<\/i>\n                    To Overcome Calprotectin-Mediated Stress"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5182-796X","authenticated-orcid":false,"given":"Lindsey R.","family":"Burcham","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoann","family":"Le Breton","sequence":"additional","affiliation":[{"name":"Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana N.","family":"Radin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Illinois at Urbana\u2014Champaign, Urbana, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brady L.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lia","family":"Hiron","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tours, INRAE, ISP, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica R.","family":"Ransom","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica da C.","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashton T.","family":"Belew","sequence":"additional","affiliation":[{"name":"Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA"},{"name":"Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7970-3312","authenticated-orcid":false,"given":"Najib M.","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA"},{"name":"Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4769-4463","authenticated-orcid":false,"given":"Kevin S.","family":"McIver","sequence":"additional","affiliation":[{"name":"Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8234-1113","authenticated-orcid":false,"given":"Thomas E.","family":"Kehl-Fie","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Illinois at Urbana\u2014Champaign, Urbana, Illinois, USA"},{"name":"Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana\u2014Champaign, Urbana, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4232-6837","authenticated-orcid":false,"given":"Kelly S.","family":"Doran","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-008-0404-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-062917-012312"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2057"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08300"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2836"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6976.12087"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152449"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003068"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002987"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03240130021018"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071816-064559"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.04.010"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.11.008"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja307974e"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b06845"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja3096416"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.07.004"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1891"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006819"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.02.011"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00779-17"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b01212"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14950"},{"key":"e_1_3_2_25_2","volume-title":"Faecal calprotectin diagnostic tests for inflammatory diseases of the bowel. Diagnostics guidance [DG11]","author":"National Institute for Health and Care Excellence","year":"2013","unstructured":"National Institute for Health and Care Excellence. 2013. Faecal calprotectin diagnostic tests for inflammatory diseases of the bowel. Diagnostics guidance [DG11]. National Institute for Health and Care Excellence, London, United Kingdom."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.05.017"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07128-1"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.27.3.1023-1032.1980"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23829"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03576.x"},{"key":"e_1_3_2_31_2","volume-title":"Active bacterial surveillance report, Emerging Infections Program Network, group B Streptococcus","author":"CDC","year":"2017","unstructured":"CDC. 2017. Active bacterial surveillance report, Emerging Infections Program Network, group B Streptococcus. Centers for Disease Control and Prevention, Atlanta, GA."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209173271208"},{"key":"e_1_3_2_33_2","volume-title":"Neonatal meningitis","author":"Bundy LM","year":"2020","unstructured":"Bundy LM, Noor A. 2020. Neonatal meningitis. StatPearls Publishing, Treasure Island, FL."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3453"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00139"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1086\/338475"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1474"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007848"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00019"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.4.462"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00614-16"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00757-18"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07862.x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12504"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146785"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152835"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.59.1.204-210.1991"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00870-14"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/152.2.323"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226699"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep09838"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00062-18"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt043"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-008-9291-6"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-015-9826-z"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06638.x"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2656-2664.2003"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13335"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0409OC"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)89421-2"},{"key":"e_1_3_2_61_2","first-page":"460","article-title":"Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells","volume":"42","author":"Hyun HJ","year":"2001","unstructured":"Hyun HJ, Sohn JH, Ha DW, Ahn YH, Koh JY, Yoon YH. 2001. Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 42:460\u2013465.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00673.x"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1159\/000201441"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000639"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2741-z"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07339.x"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC10174J"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R116.742023"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20170228"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03314"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01281-17"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.5111879.x"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.1.102-127.2005"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.9.4859-4869.2002"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.2.871-878.1999"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.2.993-997.2002"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00762-17"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003143"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00319-16"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506758102"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13654"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu053"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00975-15"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05849.x"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01878-07"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-5084-0"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2020.01.010"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep10799"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14314"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1638"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068694"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00097-20"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1159\/000347132"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.14"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2602"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0251-4"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00642-18"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00420-13"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780471729259.mc09d03s30"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00837-12"},{"key":"e_1_3_2_101_2","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2013","unstructured":"R Core Team. 2013. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria."},{"key":"e_1_3_2_102_2","volume-title":"Fastqc: a quality control tool for high throughput sequence data","author":"Andrews S","year":"2010","unstructured":"Andrews S. 2010. Fastqc: a quality control tool for high throughput sequence data. Babraham Bioinformatics, Babraham Institute, Cambridge, United Kingdom."},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi1107s32"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-3-r25"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbs046"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043012"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1085"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0721-2"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu031"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl1018"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1048"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn757"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02302-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02302-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T22:11:57Z","timestamp":1646691117000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.02302-20"}},"subtitle":[],"editor":[{"given":"Laura","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Larry S.","family":"McDaniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,22]]},"references-count":114,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12,22]]}},"alternative-id":["10.1128\/mBio.02302-20"],"URL":"https:\/\/doi.org\/10.1128\/mbio.02302-20","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.08.14.252064","asserted-by":"object"}]},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,22]]},"assertion":[{"value":"2020-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02302-20"}}