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The etiology of PTLDS is not understood, and objective diagnostic tools are lacking. PTLDS symptoms overlap several diseases in which patients exhibit alterations in their microbiome. We found that patients with PTLDS have a distinct microbiome signature, allowing for an accurate classification of over 80% of analyzed cases. The signature is characterized by an increase in\n            <jats:italic>Blautia<\/jats:italic>\n            , a decrease in\n            <jats:italic>Bacteroides<\/jats:italic>\n            , and other changes. Importantly, this signature supports the validity of PTLDS and is the first potential biological diagnostic tool for the disease.\n          <\/jats:p>","DOI":"10.1128\/mbio.02310-20","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T14:26:19Z","timestamp":1601303179000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients"],"prefix":"10.1128","volume":"11","author":[{"given":"Madeleine","family":"Morrissette","sequence":"first","affiliation":[{"name":"Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Pitt","sequence":"additional","affiliation":[{"name":"Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, 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