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Caspofungin is a member of a new class of clinically approved echinocandin drugs to treat invasive aspergillosis by blocking \u03b2-1,3-glucan synthase, thus damaging the fungal cell wall. Here, we demonstrate that caspofungin and other cell wall stressors can induce galactosaminogalactan (GAG)-dependent biofilm formation in the human pathogen\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            . We further identified SomA as a master transcription factor playing a dual role in both biofilm formation and cell wall homeostasis. SomA plays this dual role by direct binding to a conserved motif upstream of GAG biosynthetic genes and genes involved in cell wall stress sensors, chitin synthases, and \u03b2-1,3-glucan synthase. Collectively, these findings reveal a transcriptional control pathway that integrates biofilm formation and cell wall homeostasis and suggest SomA as an attractive target for antifungal drug development.\n          <\/jats:p>","DOI":"10.1128\/mbio.02329-20","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T14:29:54Z","timestamp":1604932194000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["The Transcription Factor SomA Synchronously Regulates Biofilm Formation and Cell Wall Homeostasis in\n            <i>Aspergillus fumigatus<\/i>"],"prefix":"10.1128","volume":"11","author":[{"given":"Yuan","family":"Chen","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, 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