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To cause invasive meningococcal diseases (IMD) such as sepsis and meningitis,\n            <jats:named-content content-type=\"genus-species\">N. meningitidis<\/jats:named-content>\n            passes through epithelial and endothelial barriers and infiltrates into blood and cerebrospinal fluid as well as epithelial and endothelial cells. However, meningococcal nutrients, including cysteine, become less abundant when it more deeply infiltrates the human body even during inflammation, such that\n            <jats:named-content content-type=\"genus-species\">N. meningitidis<\/jats:named-content>\n            has to acquire nutrients in order to survive\/persist, disseminate, and proliferate in humans. This was the first study to examine the relationship between meningococcal cysteine acquisition and the pathogenesis of meningococcal infections. The results of the present study provide insights into the mechanisms by which pathogens with auxotrophs acquire nutrients in hosts and may also contribute to the development of treatments and prevention strategies for IMD.\n          <\/jats:p>","DOI":"10.1128\/mbio.02332-18","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T09:30:16Z","timestamp":1544434216000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["The Meningococcal Cysteine Transport System Plays a Crucial Role in\n            <i>Neisseria meningitidis<\/i>\n            Survival in Human Brain Microvascular Endothelial Cells"],"prefix":"10.1128","volume":"9","author":[{"given":"Hideyuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan"},{"name":"School of Medicine, International University of Health and Welfare, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"RIKEN Structural Biology Laboratory, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"RIKEN Structural Biology Laboratory, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2015.12.016"},{"key":"e_1_3_3_3_2","first-page":"237","article-title":"Meningococcal disease: changes in epidemiology and prevention","volume":"4","author":"Chang Q","year":"2012","unstructured":"Chang Q, Tzeng YL, Stephens DS. 2012. 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