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One prominent fungal pathogen,\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus neoformans<\/jats:named-content>\n                    , causes meningitis in people suffering from HIV\/AIDS. In the present study, we focused on characterizing mechanisms by which\n                    <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n                    senses iron availability because iron is both a signal and a key nutrient for proliferation of the pathogen in vertebrate hosts. Specifically, we characterized a monothiol glutaredoxin protein, Grx4, that functions as a sensor of iron availability and interacts with regulatory factors to control the ability of\n                    <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n                    to cause disease. Grx4 regulates key virulence factors, and a mutant is unable to cause disease in a mouse model of cryptococcosis. Overall, our study provides new insights into nutrient sensing and the role of iron in the pathogenesis of fungal diseases.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02377-18","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T06:08:31Z","timestamp":1543817311000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":57,"title":["The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans"],"prefix":"10.1128","volume":"9","author":[{"given":"Rodgoun","family":"Attarian","sequence":"first","affiliation":[{"name":"Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, 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