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The bacteria grow intracellularly in free-living amoebae as well as in respiratory tract macrophages. To this end,\n            <jats:named-content content-type=\"genus-species\">L. pneumophila<\/jats:named-content>\n            forms a distinct membrane-bound compartment called the\n            <jats:italic>Legionella<\/jats:italic>\n            -containing vacuole (LCV). Phosphoinositide (PI) lipids are crucial regulators of the identity and dynamics of host cell organelles. The PI lipid PtdIns(4)\n            <jats:italic>P<\/jats:italic>\n            is a hallmark of the host cell secretory pathway, and decoration of LCVs with this PI is required for pathogen vacuole maturation. The source, dynamics, and mode of accumulation of PtdIns(4)\n            <jats:italic>P<\/jats:italic>\n            on LCVs are largely unknown. Using\n            <jats:italic>Dictyostelium<\/jats:italic>\n            amoebae producing different fluorescent probes as host cells, we show here that LCVs rapidly acquire PtdIns(4)\n            <jats:italic>P<\/jats:italic>\n            through the continuous interaction with PtdIns(4)\n            <jats:italic>P<\/jats:italic>\n            -positive host vesicles derived from the Golgi apparatus. Thus, the PI lipid pattern of the secretory pathway contributes to the formation of the replication-permissive pathogen compartment.\n          <\/jats:p>","DOI":"10.1128\/mbio.02420-18","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T09:30:16Z","timestamp":1544434216000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["<i>Legionella<\/i>\n            -Containing Vacuoles Capture PtdIns(4)\n            <i>P<\/i>\n            -Rich Vesicles Derived from the Golgi Apparatus"],"prefix":"10.1128","volume":"9","author":[{"given":"Stephen","family":"Weber","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, University of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Steiner","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of 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