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Current drugs are expensive, toxic, and highly impractical to administer, prompting the community to explore various unique aspects of\n            <jats:named-content content-type=\"genus-species\">T. brucei<\/jats:named-content>\n            biology in search of better treatments. In this study, we identified the protein arginine methyltransferase (PRMT),\n            <jats:italic>Tb<\/jats:italic>\n            PRMT1, as a factor that modulates numerous aspects of\n            <jats:named-content content-type=\"genus-species\">T. brucei<\/jats:named-content>\n            biology. These include glycolysis and life cycle progression signaling, both of which are being intensely researched toward identification of potential drug targets. Our data will aid research in those fields. Furthermore, we demonstrate for the first time a direct association of a PRMT with nucleic acids, a finding we believe could translate to other organisms, including humans, thereby impacting research in fields as distant as human cancer biology and immune response modulation.\n          <\/jats:p>","DOI":"10.1128\/mbio.02430-18","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T10:59:50Z","timestamp":1545044390000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response"],"prefix":"10.1128","volume":"9","author":[{"given":"Lucie","family":"Kafkov\u00e1","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, 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