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To date, the bone-building cells, osteoblasts, have been implicated in the progression of these infections, but not much is known about how the bone-resorbing cells, osteoclasts, participate. In this study, we show that\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    can infect osteoclasts and proliferate inside these cells, whereas bone-residing macrophages, immune cells related to osteoclasts, destroy the bacteria. These findings elucidate a unique role for osteoclasts to harbor bacteria during infection, providing a possible mechanism by which bacteria could evade destruction by the immune system.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02447-19","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T07:07:28Z","timestamp":1571036848000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":118,"title":["Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly"],"prefix":"10.1128","volume":"10","author":[{"given":"Jennifer L.","family":"Krauss","sequence":"first","affiliation":[{"name":"Division of Bone &amp; Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0855-8423","authenticated-orcid":false,"given":"Philip M.","family":"Roper","sequence":"additional","affiliation":[{"name":"Division of Bone &amp; Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ballard","sequence":"additional","affiliation":[{"name":"Division of Bone &amp; Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Cheng","family":"Shih","sequence":"additional","affiliation":[{"name":"Washington University Center for Cellular Imaging, Washington University School of Medicine, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A. 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