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Despite advances in the use of antibiotics, permanent reductions in joint function due to joint deformation and deleterious contractures occur in up to 50% of patients with septic arthritis. So far, it is still largely unknown how\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            initiates and establishes joint infection. Here, we demonstrate that von Willebrand factor-binding protein expressed by\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            facilitates the initiation of septic arthritis. Such effect might be mediated through its interaction with a host factor (von Willebrand factor). Our finding contributes significantly to the full understanding of septic arthritis etiology and will pave the way for new therapeutic modalities for this devastating disease.\n          <\/jats:p>","DOI":"10.1128\/mbio.02472-20","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T13:59:50Z","timestamp":1605535190000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["The Expression of von Willebrand Factor-Binding Protein Determines Joint-Invading Capacity of Staphylococcus aureus, a Core Mechanism of Septic Arthritis"],"prefix":"10.1128","volume":"11","author":[{"given":"Manli","family":"Na","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Inflammation Research, Institution of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, 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