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There is currently no licensed vaccine to prevent\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            infection, and its treatment has become increasingly difficult due to antibiotic resistance. One potential way to inhibit\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            pathogenesis is to prevent iron acquisition. The iron-regulated surface determinant (Isd) system has evolved in\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            to acquire hemoglobin from the human host as a source of heme-iron. In this study, we investigated the molecular and structural basis for antibody-mediated correlates against a member of the Isd system, IsdB. The association of immunoglobulin heavy chain variable region\n            <jats:italic>IGHV1-69<\/jats:italic>\n            gene-encoded human monoclonal antibodies with the response against\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            IsdB is described using structural and functional studies to define the importance of this antibody class. We also determine that somatic hypermutation in the development of these antibodies hinders rather than fine-tunes the immune response to IsdB.\n          <\/jats:p>","DOI":"10.1128\/mbio.02473-19","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T12:34:44Z","timestamp":1571661284000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Human\n            <i>\n              V\n              <sub>H<\/sub>\n              1-69\n            <\/i>\n            Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis"],"prefix":"10.1128","volume":"10","author":[{"given":"Monique R.","family":"Bennett","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, 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