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Understanding of pathogen relatedness and biology is imperative for tracking outbreaks and developing therapeutics. Here, we detail the phylogenetic structure of 145\n            <jats:named-content content-type=\"genus-species\">K. variicola<\/jats:named-content>\n            genomes from different continents. Our results have important clinical ramifications as high-risk antibiotic resistance genes are present in\n            <jats:named-content content-type=\"genus-species\">K. variicola<\/jats:named-content>\n            genomes from a variety of geographic locations and as we demonstrate that\n            <jats:named-content content-type=\"genus-species\">K. variicola<\/jats:named-content>\n            clinical isolates can establish higher bladder titers than\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            . Differential presence of these pilus genes in\n            <jats:named-content content-type=\"genus-species\">K. variicola<\/jats:named-content>\n            isolates may indicate adaption for specific environmental niches. Therefore, due to the potential of multidrug resistance and pathogenic efficacy, identification of\n            <jats:named-content content-type=\"genus-species\">K. variicola<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            to a species level should be performed to optimally improve patient outcomes during infection. This work provides a foundation for our improved understanding of\n            <jats:named-content content-type=\"genus-species\">K. variicola<\/jats:named-content>\n            biology and pathogenesis.\n          <\/jats:p>","DOI":"10.1128\/mbio.02481-18","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T10:59:50Z","timestamp":1545044390000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":87,"title":["Population Structure, Antibiotic Resistance, and Uropathogenicity of Klebsiella variicola"],"prefix":"10.1128","volume":"9","author":[{"given":"Robert F.","family":"Potter","sequence":"first","affiliation":[{"name":"The Edison Family Center for Genome Sciences and Systems Biology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, 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