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Bacteria use cyclic dinucleotides as second messengers to regulate a number of physiological processes, such as the fundamental life style transition between motility and sessility (biofilm formation). cGAMP, which is synthesized by a dinucleotide cyclase called DncV, is a newly discovered second messenger involved in virulence and chemotaxis in the\n            <jats:named-content content-type=\"genus-species\">Vibrio cholerae<\/jats:named-content>\n            biovar El Tor causing the current 7th cholera pandemic. However, to what extent cGAMP exists and participates in physiological processes in other bacteria is still unknown. In this study, we found an elevated cGAMP level to possibly regulate biofilm formation and motility in the animal commensal\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            strain ECOR31. Thus, we detected a novel role for cGAMP signaling in regulation of physiological processes other than those previously reported in proteobacterial species.\n          <\/jats:p>","DOI":"10.1128\/mbio.02492-18","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T10:36:13Z","timestamp":1551695773000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["DncV Synthesizes Cyclic GMP-AMP and Regulates Biofilm Formation and Motility in\n            <i>Escherichia coli<\/i>\n            ECOR31"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5102-6284","authenticated-orcid":false,"given":"Fengyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 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