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However, infection of\n            <jats:italic>Ae. aegypti<\/jats:italic>\n            with the insect endosymbiotic bacterium,\n            <jats:italic>Wolbachia<\/jats:italic>\n            , reduces the risk of mosquito to human viral transmission.\n            <jats:italic>Wolbachia<\/jats:italic>\n            is being utilized at field sites across more than 13 countries to reduce the incidence of viruses like dengue, but it is not well understood how\n            <jats:italic>Wolbachia<\/jats:italic>\n            induces its antiviral effects. To examine this at the subcellular level, we compared how different strains of\n            <jats:italic>Wolbachia<\/jats:italic>\n            with varying antiviral strengths associate with and modify host cell structures. Strongly antiviral strains were found to specifically associate with the host endoplasmic reticulum and induce striking impacts on host cell lipid droplets. Inhibiting\n            <jats:italic>Wolbachia<\/jats:italic>\n            -induced lipid redistribution partially restored dengue virus replication demonstrating this is a contributing role for\n            <jats:italic>Wolbachia's<\/jats:italic>\n            antiviral activity. These findings provide new insights into how antiviral\n            <jats:italic>Wolbachia<\/jats:italic>\n            strains associate with and modify\n            <jats:italic>Ae. aegypti<\/jats:italic>\n            host cells.\n          <\/jats:p>","DOI":"10.1128\/mbio.02495-23","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T13:52:22Z","timestamp":1703253142000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Antiviral\n            <i>Wolbachia<\/i>\n            strains associate with\n            <i>Aedes aegypti<\/i>\n            endoplasmic reticulum membranes and induce lipid droplet formation to restrict dengue virus replication"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8645-5158","authenticated-orcid":false,"given":"Robson K.","family":"Loterio","sequence":"first","affiliation":[{"name":"Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebony A.","family":"Monson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Anatomy, Physiology and Pharmacology; 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