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Here, we identified an M-like protein, SzM, and its positive regulator, SezV, in\n            <jats:named-content content-type=\"genus-species\">Streptococcus equi<\/jats:named-content>\n            subspecies\n            <jats:italic>zooepidemicus<\/jats:italic>\n            (SEZ), an important group of pathogens for domesticated animals, including horses and pigs. SzM and SezV homologues were found in the genomes of all SEZ and\n            <jats:named-content content-type=\"genus-species\">S. equi<\/jats:named-content>\n            subspecies\n            <jats:italic>equi<\/jats:italic>\n            and M18 group A streptococcal strains analyzed but not in other streptococci. Mutant SEZ strains lacking either\n            <jats:italic>sezV<\/jats:italic>\n            or\n            <jats:italic>szM<\/jats:italic>\n            were highly attenuated in a mouse model of infection. 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