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Another concern is that patients at risk for developing OPC often take long courses of antifungal drugs, which can lead to the emergence of drug-resistant\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            strains. We therefore identified nine mutants with defects in undergoing invasive hyphal growth in the oral cavity, increasing the number of genes known to be involved in OPC by more than 30%. The two strongest mutants,\n            <jats:italic>rvs161<\/jats:italic>\n            \u0394 and\n            <jats:italic>rvs167<\/jats:italic>\n            \u0394, have defects in endocytosis. The\n            <jats:italic>rvs<\/jats:italic>\n            \u0394 mutants appear to have a specific defect in initiating invasive growth, as preinducing the cells to form hyphae prior to infection restored their ability to cause OPC. These results indicate that blocking endocytosis could have therapeutic value in preventing the initiation of OPC without leading to development of resistance against drugs currently used to treat fungal infections.\n          <\/jats:p>","DOI":"10.1128\/mbio.02503-19","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T10:50:41Z","timestamp":1573469441000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Candida albicans\n            <i>rvs161<\/i>\n            \u0394 and\n            <i>rvs167<\/i>\n            \u0394 Endocytosis Mutants Are Defective in Invasion into the Oral Cavity"],"prefix":"10.1128","volume":"10","author":[{"given":"Shamoon","family":"Naseem","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois M.","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5989-4086","authenticated-orcid":false,"given":"James B.","family":"Konopka","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006056"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00469-16"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.04.008"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens4030606"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283536ba8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511399284"},{"key":"e_1_3_3_8_2","first-page":"1304","article-title":"Candidiasis (oropharyngeal)","volume":"2013","author":"Pankhurst CL","year":"2013","unstructured":"Pankhurst CL. 2013. 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