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Rapid parasite replication is critical for establishing a productive infection. Here, we demonstrate that a\n            <jats:italic>Toxoplasma<\/jats:italic>\n            protein kinase called MAPK2 is conserved throughout the Alveolata and essential for parasite replication. We found that parasites lacking MAPK2 protein were defective in the initiation of daughter cell budding and were rendered inviable. Specifically,\n            <jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>\n            MAPK2 (TgMAPK2) appears to be required for centrosome replication at the basal end of the nucleus, and its loss causes arrest early in parasite division. MAPK2 is unique to the Alveolata and not found in metazoa and likely is a critical component of an essential parasite-specific signaling network.\n          <\/jats:p>","DOI":"10.1128\/mbio.02517-20","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T14:29:54Z","timestamp":1604932194000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Loss of the Conserved Alveolate Kinase MAPK2 Decouples\n            <i>Toxoplasma<\/i>\n            Cell Growth from Cell Division"],"prefix":"10.1128","volume":"11","author":[{"given":"Xiaoyu","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"O\u2019Shaughnessy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of 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