{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:39:56Z","timestamp":1790991596391,"version":"4.1.0"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:00:00Z","timestamp":1551139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,2,26]]},"abstract":"<jats:p>\n            Fungal pathogens pose a serious threat to public health.\n            <jats:named-content content-type=\"genus-species\">Candida auris<\/jats:named-content>\n            is an emerging fungal pathogen that is often resistant to commonly used antifungal drugs. However, the mechanisms governing drug resistance and virulence in this organism remain largely unexplored. In this study, we adapted a conditional expression system to modulate the transcription of an essential gene,\n            <jats:italic>HSP90<\/jats:italic>\n            , which regulates antifungal resistance and virulence in diverse fungal pathogens. We showed that Hsp90 is essential for growth in\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            and is important for tolerance of the clinically important azole antifungals, which block ergosterol biosynthesis. Further, we established that the Cdr1 efflux transporter regulates azole resistance. Finally, we discovered that\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            transitions from yeast to filamentous growth in response to Hsp90 inhibition, accompanied by global transcriptional remodeling. Overall, this work provides a novel insight into mechanisms regulating azole resistance in\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            and uncovers a distinct developmental program regulated by Hsp90.\n          <\/jats:p>","DOI":"10.1128\/mbio.02529-18","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T11:50:49Z","timestamp":1548676249000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":99,"title":["Genetic Analysis of\n            <i>Candida auris<\/i>\n            Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-0623","authenticated-orcid":false,"given":"Sang Hu","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics, University of Toronto, Toronto, 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