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We investigated the potential of targeting mitochondria, which are organelles required for energy production, growth, and virulence, in the human fungal pathogen\n                    <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n                    . Our findings suggest that mitochondria can be targeted using drugs that can be tolerated by humans and that this treatment enhances their recognition by immune cells. However, release of\n                    <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n                    cells from respiratory inhibition appears to activate a stress response that increases the levels of traits associated with virulence. Our results make it clear that mitochondria represent a valid target for the development of antifungal strategies but that we must determine the mechanisms by which they regulate stress signaling and virulence ahead of successful therapeutic advance.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02535-18","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T06:50:49Z","timestamp":1548658249000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":62,"title":["Inhibition of Classical and Alternative Modes of Respiration in\n                    <i>Candida albicans<\/i>\n                    Leads to Cell Wall Remodeling and Increased Macrophage Recognition"],"prefix":"10.1128","volume":"10","author":[{"given":"Lucian","family":"Duvenage","sequence":"first","affiliation":[{"name":"Kent Fungal Group, School of Biosciences, University of Kent, Kent, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2236-8776","authenticated-orcid":false,"given":"Louise A.","family":"Walker","sequence":"additional","affiliation":[{"name":"MRC Centre for Medical Mycology at the University of Aberdeen, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Bojarczuk","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity &amp; Cardiovascular Disease and Bateson Centre, University of Sheffield, Sheffield, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity &amp; Cardiovascular Disease and Bateson Centre, University of Sheffield, Sheffield, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"MacCallum","sequence":"additional","affiliation":[{"name":"MRC Centre for Medical Mycology at the University of Aberdeen, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Munro","sequence":"additional","affiliation":[{"name":"MRC Centre for Medical Mycology at the University of Aberdeen, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2373-6788","authenticated-orcid":false,"given":"Campbell W.","family":"Gourlay","sequence":"additional","affiliation":[{"name":"Kent Fungal Group, School of Biosciences, University of Kent, Kent, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000499"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/fov027"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.05184-11"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12438"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(02)00308-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-006-9012-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1087-1845(02)00007-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-56"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005133"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.07.066"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00001-10"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/523110"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1815"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.238"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006403"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12135"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147175"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.05292-11"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02555"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs15273h"},{"key":"e_1_3_2_22_2","first-page":"s4","article-title":"Spotlight on the use of nitric oxide in dermatology: what is it? 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