{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:48:55Z","timestamp":1792075735493,"version":"4.4.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T00:00:00Z","timestamp":1577145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI39115-21"],"award-info":[{"award-number":["AI39115-21"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI50113-15"],"award-info":[{"award-number":["AI50113-15"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI104533-05"],"award-info":[{"award-number":["AI104533-05"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI112595-04"],"award-info":[{"award-number":["AI112595-04"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,12,24]]},"abstract":"<jats:p>\n                    The emerging fungal pathogen\n                    <jats:named-content content-type=\"genus-species\">Mucor circinelloides<\/jats:named-content>\n                    causes a severe infection, mucormycosis, which leads to considerable morbidity and mortality. Treatment of\n                    <jats:italic>Mucor<\/jats:italic>\n                    infection is challenging because\n                    <jats:italic>Mucor<\/jats:italic>\n                    is inherently resistant to nearly all clinical antifungal agents. An RNAi-dependent and reversible mechanism of antifungal resistance, epimutation, was recently reported for\n                    <jats:italic>Mucor<\/jats:italic>\n                    . Epimutation has not been studied\n                    <jats:italic>in vivo<\/jats:italic>\n                    , and it was unclear whether it would contribute to antifungal resistance observed clinically. We demonstrate that epimutation can both be induced and reverted after\n                    <jats:italic>in vivo<\/jats:italic>\n                    passage through a mouse; rates of both induction and reversion are higher after brain infection than after infection of other organs (liver, spleen, kidneys, or lungs). Elucidating the roles played by epimutation in drug resistance and infection will improve our understanding of\n                    <jats:italic>Mucor<\/jats:italic>\n                    and other fungal pathogens and may have implications for antifungal treatment.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02579-19","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T09:12:42Z","timestamp":1572945162000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":205,"title":["Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides"],"prefix":"10.1128","volume":"10","author":[{"given":"Zanetta","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Duke University, Durham, North Carolina, 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