{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:35:03Z","timestamp":1790667303370,"version":"4.1.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Wellcome Centre for Cell Matrix Research","award":["(203128\/Z\/16\/Z"],"award-info":[{"award-number":["(203128\/Z\/16\/Z"]}]},{"name":"HHS | National Institutes of Health","award":["1R01HL171283-01"],"award-info":[{"award-number":["1R01HL171283-01"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["304200\/Z\/23\/Z"],"award-info":[{"award-number":["304200\/Z\/23\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2024,12,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              The polysaccharide hyaluronan (HA) is an important component of lung extracellular matrix that increases following infection with influenza or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hellman et al. (U. Hellman, E. Rosendal, J. Lehrstrand, J. Henriksson, et al., mBio 15:e01303-24,\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.01303-24\" xlink:type=\"simple\">https:\/\/doi.org\/10.1128\/mbio.01303-24<\/jats:ext-link>\n              ) show that fragmented HA accumulates in the lungs of coronavirus disease 2019 (COVID-19) patients, with systemic levels of HA being associated with reduced lung function 3\u20136 months after infection. This study provides novel insights into HA\u2019s role in COVID-19 pathology and its potential utility as a biomarker for disease severity. However, much remains to be understood about the lung HA matrix in COVID-19 and how it compares to other lung conditions. In particular, the role of HA-binding proteins in organizing HA into a crosslinked network is yet to be fully determined at a molecular level. This knowledge is crucial in understanding the inter-relationships between the structure of the HA matrix and the regulation of the immune response, and thus our ability to target HA therapeutically for improved outcomes in COVID-19.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/mbio.02609-24","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T14:00:39Z","timestamp":1731938439000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Hyaluronan in COVID-19: a matrix for understanding lung disease"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4733-138X","authenticated-orcid":true,"given":"Rebecca J.","family":"Dodd","sequence":"first","affiliation":[{"name":"Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Academic Health Science Centre","place":["Manchester, United Kingdom"]},{"name":"Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Academic Health Science Centre","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith E.","family":"Allen","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Academic Health Science Centre","place":["Manchester, United Kingdom"]},{"name":"Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Academic Health Science Centre","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1415-3134","authenticated-orcid":true,"given":"Anthony J.","family":"Day","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Academic Health Science Centre","place":["Manchester, United Kingdom"]},{"name":"Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Academic Health Science Centre","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02787"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0036com"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0018OC"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03159"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.AC120.015967"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.150107"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.152629"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.90.1.145"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.105981"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.147472"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01303-24"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac343"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad630"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2024.01.004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/pgr2.70007"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep36928"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c06942"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06463-0"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.512491"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.06.006"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2023.06.007"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.01.011"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","unstructured":"Shah A Zhang X Snee M Lockhart-Cairns MP Levy CW Jowitt TA Birchenough HL Dean L Collins R Dodd RJ Roberts ARE Enghild JJ Mantovani A Fontana J Baldock C Inforzato A Richter RP Day AJ. 2024. 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