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The immune signaling factor interferon gamma (IFN-\u03b3) blocks\n                    <jats:named-content content-type=\"genus-species\">L. pneumophila<\/jats:named-content>\n                    replication in macrophages and is an essential component of the immune response to\n                    <jats:named-content content-type=\"genus-species\">L. pneumophila<\/jats:named-content>\n                    and other intracellular pathogens. However, to date, no study has identified the exact molecular factors induced by IFN-\u03b3 that are required for its activity. We generated macrophages lacking different combinations of IFN-\u03b3-induced genes in an attempt to find a genetic background in which there is a complete loss of IFN-\u03b3-mediated restriction of\n                    <jats:named-content content-type=\"genus-species\">L. pneumophila<\/jats:named-content>\n                    . We identified six genes that comprise the totality of the IFN-\u03b3-dependent restriction of\n                    <jats:named-content content-type=\"genus-species\">L. pneumophila<\/jats:named-content>\n                    replication in macrophages. Our results clarify the molecular basis underlying the potent effects of IFN-\u03b3 and highlight how redundancy downstream of IFN-\u03b3 is key to prevent exploitation of macrophages by pathogens.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02629-19","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T05:50:41Z","timestamp":1573451441000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila"],"prefix":"10.1128","volume":"10","author":[{"given":"Jordan V.","family":"Price","sequence":"first","affiliation":[{"name":"Department of Biology, Oberlin College, Oberlin, Ohio, 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