{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:22:22Z","timestamp":1790518942861,"version":"4.1.0"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:00:00Z","timestamp":1551139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Labex IBEID","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["AfuInf ANR-16-CE92-0039"],"award-info":[{"award-number":["AfuInf ANR-16-CE92-0039"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DEQ20150331722 LATGE Equipe FRM 2015"],"award-info":[{"award-number":["DEQ20150331722 LATGE Equipe FRM 2015"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,2,26]]},"abstract":"<jats:p>\n            The fungal cell wall is a complex and dynamic entity essential for the development of fungi. It allows fungal pathogens to survive environmental challenge posed by nutrient stress and host defenses, and it also is central to polarized growth. The cell wall is mainly composed of polysaccharides organized in a three-dimensional network.\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            produces a cell wall galactomannan whose biosynthetic pathway and biological functions remain poorly defined. Here, we described two new mannosyltransferases essential to the synthesis of the cell wall galactomannan. Their absence leads to a growth defect with misregulation of polarization and altered conidiation, with conidia which are bigger and more permeable than the conidia of the parental strain. This study showed that in spite of its low concentration in the cell wall, this polysaccharide is absolutely required for cell wall stability, for apical growth, and for the full virulence of\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/mbio.02647-18","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T11:52:24Z","timestamp":1549885944000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Two KTR Mannosyltransferases Are Responsible for the Biosynthesis of Cell Wall Mannans and Control Polarized Growth in\n            <i>Aspergillus fumigatus<\/i>"],"prefix":"10.1128","volume":"10","author":[{"given":"Christine","family":"Henry","sequence":"first","affiliation":[{"name":"Aspergillus Unit, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhou","family":"Li","sequence":"additional","affiliation":[{"name":"Aspergillus Unit, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-0658","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Danion","sequence":"additional","affiliation":[{"name":"Aspergillus Unit, Institut Pasteur, Paris, France"},{"name":"Necker-Enfants Malades Hospital, Department of Infectious Diseases and Tropical Medicine, Paris Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Alcazar-Fuoli","sequence":"additional","affiliation":[{"name":"Spanish Network for Research in Infectious Diseases (REIPI RD16\/0016), ISCIII, Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Mellado","sequence":"additional","affiliation":[{"name":"Spanish Network for Research in Infectious Diseases (REIPI RD16\/0016), ISCIII, Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Beau","sequence":"additional","affiliation":[{"name":"Aspergillus Unit, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Jouvion","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Neuropathologie Exp\u00e9rimentale, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Latg\u00e9","sequence":"additional","affiliation":[{"name":"Aspergillus Unit, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Aspergillus Unit, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70080"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwn044"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07164.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00221-08"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003276"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00371-08"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M909975199"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof2030022"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.10.005"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900961"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02488-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.12.5424-5433.1994"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12665"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.1798"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.24.15527"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12630"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00882-10"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.7.1308-1316.2005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwv078"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/1.4.387"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2009.02.013"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.2.423"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.10.6579"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208023200"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2014.06.010"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12326"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.20.14882"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00107-10"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2016.1179092"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00068-17"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2003.11.007"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myw085"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12877"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.05270-11"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003575"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117336"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12416"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwx028"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01352.x"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.398321"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(98)00133-0"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.41.26836"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwv094"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.5.1.207-211.2006"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6593(66)80120-0"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.6.1547-1554.1993"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01368-07"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05661-11"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac60111a017"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.547034"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-022-5_1"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.130022"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/130.2.273"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12426"}],"container-title":["mBio"],"original-title":[],"contributor":[{"given":"Axel","family":"Brakhage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Aaron","family":"Nieman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Dimitrios","family":"Kontoyiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02647-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02647-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T02:27:18Z","timestamp":1646706438000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.02647-18"}},"subtitle":[],"editor":[{"given":"Bernhard","family":"Hube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,26]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2,26]]}},"alternative-id":["10.1128\/mBio.02647-18"],"URL":"https:\/\/doi.org\/10.1128\/mbio.02647-18","relation":{},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,26]]},"assertion":[{"value":"2018-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02647-18"}}