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The U.S. Centers for Disease Control and Prevention has listed carbapenem-resistant\n                    <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n                    (CR\n                    <jats:italic>-Kp<\/jats:italic>\n                    ) as an urgent public health threat. Dense colonization of the intestine by CR\n                    <jats:italic>-Kp<\/jats:italic>\n                    and other antibiotic-resistant bacteria is associated with an increased risk of bacteremia. Reducing the density of gut colonization by CR\n                    <jats:italic>-Kp<\/jats:italic>\n                    is likely to reduce their transmission from patient to patient in health care facilities as well as systemic infections. How CR\n                    <jats:italic>-Kp<\/jats:italic>\n                    expands and persists in the gut lumen, however, is poorly understood. Herein, we generated a highly saturated mutant library in a multidrug-resistant\n                    <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n                    strain and identified genetic factors that are associated with dense gut colonization by\n                    <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n                    . This study sheds light on host colonization by\n                    <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n                    and identifies potential colonization factors that contribute to high-density persistence of\n                    <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n                    in the intestine.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02663-18","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T06:43:59Z","timestamp":1552286639000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Genome-Wide Screening for Enteric Colonization Factors in Carbapenem-Resistant ST258 Klebsiella pneumoniae"],"prefix":"10.1128","volume":"10","author":[{"given":"Hea-Jin","family":"Jung","sequence":"first","affiliation":[{"name":"Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Littmann","sequence":"additional","affiliation":[{"name":"Center for Microbes, Inflammation, and Cancer, Molecular Microbiology Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Seok","sequence":"additional","affiliation":[{"name":"Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid M.","family":"Leiner","sequence":"additional","affiliation":[{"name":"Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, 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