{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:33:18Z","timestamp":1783747998328,"version":"3.55.0"},"reference-count":86,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"European Union Horizon 2020","award":["MSCA-ITN GA 675278 EDGE"],"award-info":[{"award-number":["MSCA-ITN GA 675278 EDGE"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB900 158989968"],"award-info":[{"award-number":["SFB900 158989968"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Culture, Lower Saxony, Germany","award":["SMART BIOTECS alliance"],"award-info":[{"award-number":["SMART BIOTECS alliance"]}]},{"DOI":"10.13039\/501100009318","name":"Helmholtz Association","doi-asserted-by":"publisher","award":["W2\/W3-090"],"award-info":[{"award-number":["W2\/W3-090"]}],"id":[{"id":"10.13039\/501100009318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2021,6,29]]},"abstract":"<jats:p>Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire of drugs, often accompanied by the occurrence of resistant mutants.<\/jats:p>","DOI":"10.1128\/mbio.02683-20","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T07:48:51Z","timestamp":1620028131000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral\n                    <i>UL4<\/i>\n                    \/\n                    <i>UL5<\/i>\n                    Transcripts"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8674-1525","authenticated-orcid":true,"given":"Ana Cristina","family":"Gonzalez-Perez","sequence":"first","affiliation":[{"name":"Viral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9240-3987","authenticated-orcid":true,"given":"Markus","family":"Stempel","sequence":"additional","affiliation":[{"name":"Viral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany"},{"name":"Institute of Genetics, Technische Universit\u00e4t Braunschweig, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Wyler","sequence":"additional","affiliation":[{"name":"Berlin Institute for Medical Systems Biology, Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Urban","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Virology, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Piras","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Virology, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-1681","authenticated-orcid":true,"given":"Thomas","family":"Hennig","sequence":"additional","affiliation":[{"name":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Helmholtz-Institute for RNA-based Infection Research, HIRI, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Ganskih","sequence":"additional","affiliation":[{"name":"Helmholtz-Institute for RNA-based Infection Research, HIRI, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjie","family":"Wei","sequence":"additional","affiliation":[{"name":"Helmholtz-Institute for RNA-based Infection Research, HIRI, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9447-1561","authenticated-orcid":true,"given":"Albert","family":"Heim","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Landthaler","sequence":"additional","affiliation":[{"name":"Berlin Institute for Medical Systems Biology, Max-Delbr\u00fcck-Center for Molecular Medicine, Berlin, Germany"},{"name":"IRI Life Sciences, Institute of Biology, Humboldt-Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pichlmair","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Virology, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"D\u00f6lken","sequence":"additional","affiliation":[{"name":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Helmholtz-Institute for RNA-based Infection Research, HIRI, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Munschauer","sequence":"additional","affiliation":[{"name":"Helmholtz-Institute for RNA-based Infection Research, HIRI, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Erhard","sequence":"additional","affiliation":[{"name":"Institute for Virology and Immunobiology, Julius-Maximilians-Universit\u00e4t W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5431-6527","authenticated-orcid":true,"given":"Melanie M.","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Viral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany"},{"name":"Institute of Genetics, Technische Universit\u00e4t Braunschweig, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198503000-00003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.3.478"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00505.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.9.1068"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12862"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120231"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00124"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00715-19"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0040021"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302564110"},{"key":"e_1_3_2_12_2","first-page":"541","article-title":"Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31","volume":"23","author":"Katoh M","year":"2003","unstructured":"Katoh M, Katoh M. 2003. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. Int J Oncol 23:541\u2013547.","journal-title":"Int J Oncol"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0968-0004(01)01787-x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607063104"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.23.12781-12787.2004"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.5.2.6044"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101676108"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.21.11555-11562.2003"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01601-06"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24039"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007166"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1509745112"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01909-16"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000982"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003494"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008844"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-015-0433-y"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008845"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-010-0096-9"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1913232116"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz581"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0527-6"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.028"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.26.3.686-701.1978"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.41.2.462-477.1982"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002444"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-070078"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003366"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00013-18"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4435"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty256"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6362"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3810"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr261"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09907"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49894"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006145"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00088-17"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46767"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-019-00582-0"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11995"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-9822(93)90209-7"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9543274"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.116"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.594"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74980-3_6"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18606-0"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.63.8.3330-3337.1989"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.63.1.281-290.1989"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00007-07"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2014_844"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18856-0"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.17.8596-8608.2002"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0448-2"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.22.11218-11221.2001"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050166"},{"key":"e_1_3_2_67_2","first-page":"57","volume-title":"Progress in cytomegalovirus research: proceedings of the Third International Cytomegalovirus Workshop.","author":"Ripalti A","year":"1991","unstructured":"Ripalti A, Mocarski ES. 1991. The products of human cytomegalovirus genes UL1-UL7, including gp48, are dispensable for growth in cell culture, p 57\u201360, In Landini MP (ed), Progress in cytomegalovirus research: proceedings of the Third International Cytomegalovirus Workshop. Elsevier Science Publishers, Bologna, Italy."},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90413-6"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2019.10.018"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.83286-0"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2951"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(89)90129-8"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1012-2"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23285"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0323-3"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.136"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu781"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks042"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98141-3"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty471"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw257"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1106"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02683-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02683-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T22:41:09Z","timestamp":1646692869000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.02683-20"}},"subtitle":[],"editor":[{"given":"Stacy M.","family":"Horner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,6,29]]},"references-count":86,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6,29]]}},"alternative-id":["10.1128\/mBio.02683-20"],"URL":"https:\/\/doi.org\/10.1128\/mbio.02683-20","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.09.15.297804","asserted-by":"object"}]},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,29]]},"assertion":[{"value":"2020-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02683-20"}}