{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:14:40Z","timestamp":1790781280632,"version":"4.1.0"},"reference-count":73,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:00:00Z","timestamp":1551139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI123162"],"award-info":[{"award-number":["R01 AI123162"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21 CA206309"],"award-info":[{"award-number":["R21 CA206309"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R37 AI064046"],"award-info":[{"award-number":["R37 AI064046"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["no number"],"award-info":[{"award-number":["no number"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,2,26]]},"abstract":"<jats:p>\n                    The APOBEC3B DNA cytosine deaminase is overexpressed in many different cancers and correlates with elevated frequencies of C-to-T and C-to-G mutations in 5\u2032-TC motifs, oncogene activation, acquired drug resistance, and poor clinical outcomes. The mechanisms responsible for APOBEC3B overexpression are not fully understood. Here, we show that the polyomavirus truncated T antigen (truncT) triggers APOBEC3B overexpression through its RB-interacting motif, LXCXE, which in turn likely modulates the binding of E2F family transcription factors to promote\n                    <jats:italic>APOBEC3B<\/jats:italic>\n                    expression. This work strengthens the mechanistic linkage between active cell cycling, APOBEC3B overexpression, and cancer mutagenesis. Although this mutational mechanism damages cellular genomes, viruses may leverage it to promote evolution, immune escape, and pathogenesis. The cellular portion of the mechanism may also be relevant to nonviral cancers, where genetic mechanisms often activate the RB\/E2F axis and APOBEC3B mutagenesis contributes to tumor evolution.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02690-18","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T07:11:21Z","timestamp":1549264281000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Polyomavirus T Antigen Induces\n                    <i>APOBEC3B<\/i>\n                    Expression Using an LXCXE-Dependent and TP53-Independent Mechanism"],"prefix":"10.1128","volume":"10","author":[{"given":"Gabriel J.","family":"Starrett","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur A.","family":"Serebrenik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter A.","family":"Roelofs","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Radiotherapy and OncoImmunology Laboratory, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"McCann","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandy","family":"Verhalen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teneale A.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily K.","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel","family":"Krupp","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology, Biogen, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W. M.","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Cahir-McFarland","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology, Biogen, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1930-6638","authenticated-orcid":false,"given":"Paul N.","family":"Span","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Radiotherapy and OncoImmunology Laboratory, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben S.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA"},{"name":"Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01425-16"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002251"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005574"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2323"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2299-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00771-16"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vev015"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03091-13"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153201"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.04.005"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2701"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3344"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15024"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.197046.115"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.050"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11383"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.01.021"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522325113"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.03.012"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-6-229"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/683095"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy003"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02234-14"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.03.068"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02413-16"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02383-14"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb08091.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05608.x"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.03.027"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.009159-0"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2992"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90983-5"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.6.3945-3948.1995"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.6.1449"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1601737"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-2171-T"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-014-0196-8"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx721"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.3.4.801"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1293"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05678.x"},{"key":"e_1_3_3_43_2","first-page":"1169","article-title":"WAF1\/CIP1 is induced in p53-mediated G1 arrest and apoptosis","volume":"54","author":"El-Deiry WS","year":"1994","unstructured":"El-Deiry WS, Harper JW, O\u2019Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, Wiman KG, Mercer WE, Kastan MB, Kohn KW, Elledge SJ, Kinzler KW, Vogelstein B. 1994. WAF1\/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54:1169\u20131174.","journal-title":"Cancer Res"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01119"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.09.009"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14344"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/334124a0"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209681"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/1747-1028-7-10"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.5135"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.4.2378-2386.1996"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.02.008"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4504"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.26"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11881"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.133"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.138"},{"key":"e_1_3_3_58_2","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1158\/1535-7163.1427.3.11","article-title":"Specific inhibition of cyclin-dependent kinase 4\/6 by PD 0332991 and associated antitumor activity in human tumor xenografts","volume":"3","author":"Fry DW","year":"2004","unstructured":"Fry DW, Harvey PJ, Keller PR, Elliott WL, Meade M, Trachet E, Albassam M, Zheng X, Leopold WR, Pryer NK, Toogood PL. 2004. Specific inhibition of cyclin-dependent kinase 4\/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther 3:1427\u20131438.","journal-title":"Mol Cancer Ther"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201607084"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0830"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw523"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1217"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.07.037"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0894"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.001"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.014"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424869112"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3291"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890340211"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2910"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02169-08"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000397"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00281-10"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002898"}],"container-title":["mBio"],"original-title":[],"contributor":[{"given":"Peter","family":"Howley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Colin","family":"Crump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]},{"given":"Marcelo","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"reviewer"}]}],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02690-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02690-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T06:31:56Z","timestamp":1662877916000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.02690-18"}},"subtitle":[],"editor":[{"given":"Alan G.","family":"Barbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,26]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2,26]]}},"alternative-id":["10.1128\/mBio.02690-18"],"URL":"https:\/\/doi.org\/10.1128\/mbio.02690-18","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/312595","asserted-by":"object"}]},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,26]]},"assertion":[{"value":"2018-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02690-18"}}