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We used genomic epidemiology in a One Health study conducted in the East of England to examine putative sources of\n                    <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n                    associated with serious human disease.\n                    <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n                    from 1,517 patients with bloodstream infections were compared with 431 isolates from livestock farms and meat. Livestock-associated and bloodstream isolates were genetically distinct populations based on core genome and accessory genome analyses. Identical antimicrobial resistance genes were found in livestock and human isolates, but there was limited overlap in the mobile elements carrying these genes. Within the limitations of sampling, our findings do not support the idea that\n                    <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n                    causing invasive disease or their resistance genes are commonly acquired from livestock in our region.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02693-18","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T06:46:35Z","timestamp":1548053195000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":216,"title":["One Health Genomic Surveillance of Escherichia coli Demonstrates Distinct Lineages and Mobile Genetic Elements in Isolates from Humans versus Livestock"],"prefix":"10.1128","volume":"10","author":[{"given":"Catherine","family":"Ludden","sequence":"first","affiliation":[{"name":"London School of Hygiene &amp; Tropical Medicine, London, United Kingdom"},{"name":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy E.","family":"Raven","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Jamrozy","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Gouliouris","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, United Kingdom"},{"name":"Clinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, United Kingdom"},{"name":"Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Blane","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Coll","sequence":"additional","affiliation":[{"name":"London School of Hygiene &amp; 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