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Current therapies are not effective against all life stages of the parasite, and many cause toxic effects. The single mitochondrion of this parasite is a validated drug target, and it changes its shape throughout its life cycle. When the parasite is inside a cell, the mitochondrion adopts a lasso shape that lies in close proximity to the pellicle. The functional significance of this morphology is not understood and the proteins involved are currently not known. We have identified a protein that is required for proper mitochondrial positioning at the periphery and that likely plays a role in tethering this organelle. Loss of this protein results in dramatic changes to the mitochondrial morphology and significant parasite division and propagation defects. Our results give important insight into the molecular mechanisms regulating mitochondrial morphology.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02732-19","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T06:45:37Z","timestamp":1581317137000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Identification of Fis1 Interactors in Toxoplasma gondii Reveals a Novel Protein Required for Peripheral Distribution of the Mitochondrion"],"prefix":"10.1128","volume":"11","author":[{"given":"Kylie","family":"Jacobs","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Charvat","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Findlay, Findlay, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Arrizabalaga","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA"},{"name":"Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-3-112"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.2000.4228"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92172-c"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.021089"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.2.f1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.185165"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.01.039"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.12.048"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14138"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"Amiar S Katris NJ Berry L Dass S Shears MJ Brunet C Touquet B Hakimi M-A McFadden GI Yamaryo-Bott\u00e9 Y Bott\u00e9 CY. 2019. 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