{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:40:22Z","timestamp":1787784022955,"version":"build-2784847793"},"reference-count":67,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:00:00Z","timestamp":1551139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MO 846\/6"],"award-info":[{"award-number":["MO 846\/6"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR 124"],"award-info":[{"award-number":["TRR 124"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2019,2,26]]},"abstract":"<jats:p>\n                    Sexual reproduction is an important mechanism in the evolution of species, since it allows the combination of advantageous traits of individual members in a population. The pathogenic yeast\n                    <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n                    is a diploid organism that normally propagates in a clonal fashion, because heterozygosity at the mating type locus (\n                    <jats:italic>MTL<\/jats:italic>\n                    ) inhibits mating between cells. Here we show that\n                    <jats:italic>C.\u2009albicans<\/jats:italic>\n                    cells that have acquired drug resistance mutations during treatment with the commonly used antifungal agent fluconazole rapidly develop further increased resistance by genome rearrangements that result in simultaneous loss of heterozygosity for the mutated allele and the mating type locus. This enables the drug-resistant cells of a population to switch to the mating-competent opaque morphology and mate with each other to combine different individually acquired resistance mechanisms. The tetraploid mating products reassort their merged genomes and, under selective pressure by the drug, generate highly resistant progeny that have retained the advantageous mutated alleles. Parasexual propagation, promoted by stress-induced genome rearrangements that result in the acquisition of mating competence in cells with adaptive mutations, may therefore be an important mechanism in the evolution of\n                    <jats:italic>C.\u2009albicans<\/jats:italic>\n                    populations.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02740-18","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T07:11:21Z","timestamp":1549264281000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Evolution of Fluconazole-Resistant Candida albicans Strains by Drug-Induced Mating Competence and Parasexual Recombination"],"prefix":"10.1128","volume":"10","author":[{"given":"Christina","family":"Popp","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Molekulare Infektionsbiologie, Universit\u00e4t W\u00fcrzburg, W\u00fcrzburg, 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