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Since then, systemic\n              <jats:italic>C. auris<\/jats:italic>\n              infections have now been reported in more than 50 countries, with mortality rates of 30%\u201360%. A major contributing factor to its high inter- and intrahospital clonal transmission is that\n              <jats:italic>C. auris,<\/jats:italic>\n              unlike most\n              <jats:italic>Candida<\/jats:italic>\n              species, displays unique skin tropism and can stay on human skin for a prolonged period. However, the molecular mechanisms responsible for\n              <jats:italic>C. auris<\/jats:italic>\n              skin colonization, intradermal persistence, and systemic virulence are poorly understood. Here, we report that\n              <jats:italic>C. auris<\/jats:italic>\n              Hog1 mitogen-activated protein kinase is essential for efficient skin colonization, intradermal persistence as well as systemic virulence. RNA-seq analysis of wild-type parental and\n              <jats:italic>hog1<\/jats:italic>\n              \u0394 mutant strains revealed marked downregulation of genes involved in processes such as cell adhesion, cell wall rearrangement, and pathogenesis in\n              <jats:italic>hog1<\/jats:italic>\n              \u0394 mutant compared to the wild-type parent. Consistent with these data, we found a prominent role for Hog1 in maintaining cell wall architecture, as the\n              <jats:italic>hog1<\/jats:italic>\n              \u0394 mutant demonstrated a significant increase in cell-surface \u03b2-glucan exposure and a concomitant reduction in chitin content. Additionally, we observed that Hog1 was required for biofilm formation\n              <jats:italic>in vitro<\/jats:italic>\n              and fungal survival when challenged with primary murine macrophages and neutrophils\n              <jats:italic>ex vivo<\/jats:italic>\n              . Collectively, these findings have important implications for understanding the\n              <jats:italic>C. auris<\/jats:italic>\n              skin adherence mechanisms and penetration of skin epithelial layers preceding bloodstream infections.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              <jats:italic>Candida auris<\/jats:italic>\n              is a World Health Organization fungal priority pathogen and an urgent public health threat recognized by the Centers for Disease Control and Prevention.\n              <jats:italic>C. auris<\/jats:italic>\n              has a unique ability to colonize human skin. It also persists on abiotic surfaces in healthcare environments for an extended period of time. These attributes facilitate the inter- and intrahospital clonal transmission of\n              <jats:italic>C. auris<\/jats:italic>\n              . Therefore, understanding\n              <jats:italic>C. auris<\/jats:italic>\n              skin colonization mechanisms is critical for infection control, especially in hospitals and nursing homes. However, despite its profound clinical relevance, the molecular and genetic basis of\n              <jats:italic>C. auris<\/jats:italic>\n              skin colonization mechanisms are poorly understood. Herein, we present data on the identification of the Hog1 MAP kinase as a key regulator of\n              <jats:italic>C. auris<\/jats:italic>\n              skin colonization. These findings lay the foundation for further characterization of unique mechanisms that promote fungal persistence on human skin.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/mbio.02748-24","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T13:00:18Z","timestamp":1729256418000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["The\n            <i>Candida auris<\/i>\n            Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence"],"prefix":"10.1128","volume":"15","author":[{"given":"Raju","family":"Shivarathri","sequence":"first","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diprasom","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Karuli","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Aptekmann","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Jenull","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Medical University Vienna, Max Perutz Labs Vienna, Campus Vienna Biocenter, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-5955","authenticated-orcid":false,"given":"Karl","family":"Kuchler","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Medical University Vienna, Max Perutz Labs Vienna, Campus Vienna Biocenter, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0031-2392","authenticated-orcid":false,"given":"Shankar","family":"Thangamani","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-7462","authenticated-orcid":true,"given":"Anuradha","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8823-0796","authenticated-orcid":false,"given":"Jigar V.","family":"Desai","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9252-9897","authenticated-orcid":false,"given":"Neeraj","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00692-8"},{"key":"e_1_3_6_3_2","unstructured":"CDC. 2019. 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