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The pneumonic form of<jats:named-content content-type=\"genus-species\">Y. pestis<\/jats:named-content>infection has played a critical role in the severity of both historical and modern plague outbreaks, yet the host-pathogen interactions that govern the lethality of<jats:named-content content-type=\"genus-species\">Yersinia pestis<\/jats:named-content>pulmonary infections are incompletely understood. Here, we report that<jats:named-content content-type=\"genus-species\">Yersinia pestis<\/jats:named-content>inhibits neutrophil degranulation during infection, rendering neutrophils ineffective and allowing unrestricted growth of<jats:named-content content-type=\"genus-species\">Y. pestis<\/jats:named-content>in the lungs. This coordinated inhibition of granule release not only demonstrates the pathogenic benefit of \u201csilencing\u201d lung neutrophils but also reveals specific host processes and pathways that could be manipulated to reduce the severity of primary pneumonic plague.<\/jats:p>","DOI":"10.1128\/mbio.02759-19","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T11:07:23Z","timestamp":1575889643000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Inhibition of Neutrophil Primary Granule Release during Yersinia pestis Pulmonary Infection"],"prefix":"10.1128","volume":"10","author":[{"given":"Kara R.","family":"Eichelberger","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant S.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-6718","authenticated-orcid":false,"given":"William E.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2921"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-164023"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.008"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.04.011"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074942"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2003.09.008"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-2-3-98"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12440"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.4049\/jimmunol.154.8.4157","article-title":"Mobilization of granules and secretory vesicles during in vivo exudation of human neutrophils","volume":"154","author":"Sengel\u00f8v H","year":"1995","unstructured":"Sengel\u00f8v H, Follin P, Kjeldsen L, Lollike K, Dahlgren C, Borregaard N. 1995. 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