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The molecular processes underlying the establishment and progression of this disease are largely unknown. Our work presents a transcriptomic study to unveil the\n                    <jats:named-content content-type=\"genus-species\">Mucor circinelloides<\/jats:named-content>\n                    genetic network triggered in fungal spores in response to phagocytosis by macrophages and the transcriptional response of the host cells. Functional characterization of differentially expressed fungal genes revealed three transcription factors and three extracellular proteins essential for the fungus to survive and germinate inside the phagosome and to cause disease in mice. Two of the transcription factors, highly similar to activating transcription factors (ATFs), coordinate a complex secondary gene response involved in pathogenesis. The significance of our research is in characterizing the initial stages that lead to evasion of the host innate immune response and, in consequence, the dissemination of the infection. This genetic study offers possible targets for novel antifungal drugs against these opportunistic human pathogens.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02765-18","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T07:11:21Z","timestamp":1549264281000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["<i>Mucor circinelloides<\/i>\n                    Thrives inside the Phagosome through an Atf-Mediated Germination Pathway"],"prefix":"10.1128","volume":"10","author":[{"given":"Carlos","family":"P\u00e9rez-Arques","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica y Microbiolog\u00eda, Universidad de Murcia, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Navarro-Mendoza","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica y Microbiolog\u00eda, 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