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In this study, we found that these erythroid precursors are abundant in the human cord blood\/placental tissues, in the blood of HIV-infected and anemic individuals. We observed that these cells exacerbate HIV-1 replication\/infection in target cells and even make HIV target cells more permissible to HIV infection. In addition, we found that HIV gets a free ride by binding on the surface of these cells and thus can travel to different parts of the body. In agreement, we noticed a positive correlation between the plasma viral load and the frequency of these cells in HIV patients. More importantly, we observed that infective HIV particles reside inside these erythroid precursors but not mature red blood cells. Therefore, these cells by harboring HIV can play an important role in HIV pathogenesis.\n          <\/jats:p>","DOI":"10.1128\/mbio.02767-19","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T12:03:27Z","timestamp":1574683407000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["CD71\n            <sup>+<\/sup>\n            Erythroid Cells Exacerbate HIV-1 Susceptibility, Mediate\n            <i>trans<\/i>\n            -Infection, and Harbor Infective Viral Particles"],"prefix":"10.1128","volume":"10","author":[{"given":"Afshin","family":"Namdar","sequence":"first","affiliation":[{"name":"Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garett","family":"Dunsmore","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology 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