{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:36:52Z","timestamp":1790537812375,"version":"4.1.0"},"reference-count":80,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100015257","name":"Northeastern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The laboratory of Molecular Infection Medicine Sweden"},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Umea University"},{"DOI":"10.13039\/501100007067","name":"Kempestiftelserna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI162996"],"award-info":[{"award-number":["R01AI162996"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2021,12,21]]},"abstract":"<jats:p>\n                    To grow efficiently, resist antibiotics, and control the immune response, bacteria recycle parts of their cell wall. A key step in the typical recycling pathway is the reuse of cell wall peptides by an enzyme known as an\n                    <jats:sc>l<\/jats:sc>\n                    ,\n                    <jats:sc>d<\/jats:sc>\n                    -carboxypeptidase (LDC).\n                    <jats:named-content content-type=\"genus-species\">Acinetobacter baumannii<\/jats:named-content>\n                    , an \u201curgent-threat\u201d pathogen causing drug-resistant sepsis in hospitals, was previously thought to lack this enzymatic activity due to absence of a known LDC homolog.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02786-21","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T04:31:41Z","timestamp":1638851501000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["A New Class of Cell Wall-Recycling\n                    <scp>l<\/scp>\n                    ,\n                    <scp>d<\/scp>\n                    -Carboxypeptidase Determines \u03b2-Lactam Susceptibility and Morphogenesis in Acinetobacter baumannii"],"prefix":"10.1128","volume":"12","author":[{"given":"Yunfei","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Biology, Northeastern University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Pinedo","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Ume\u00e5 Centre for Microbial Research, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Y.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Biology, Northeastern University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-718X","authenticated-orcid":true,"given":"Felipe","family":"Cava","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Ume\u00e5 Centre for Microbial Research, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-8072","authenticated-orcid":true,"given":"Edward","family":"Geisinger","sequence":"additional","affiliation":[{"name":"Department of Biology, Northeastern University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/668770"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.296"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1398388"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30753-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18301-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107578"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.15.4108"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02185-20"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16066"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.19469"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204319200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00311"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3780"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1809285115"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1611594113"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14000"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb5614"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.089"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)81481-3"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057579"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12737"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M610911200"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12405"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00361-16"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903229106"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902026116"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00565-20"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2015.08.007"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux054"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00859-12"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07559-2"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-017-0912-8"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00766"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003016"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00027-07"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.23.6801-6808.2003"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2014.0036"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky289"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507384200"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02310-18"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.03.014"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1129"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149957"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.12.6697-6703.1990"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/297702a0"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14587"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.145.1.333-340.1981"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.168.1.199-206.1986"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806714115"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007385"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10515"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0344-3"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506328200"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2014.04.015"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704286200"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2005.06.001"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004691"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007030"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02415-19"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.022"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059388"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2010.07.002"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01076-14"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01127-19"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004401"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1754"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.77"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1377"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3676-2_2"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0554-6_12"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046688"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj014"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-018-1348-8"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.156.2.649-655.1983"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0036-z"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh378"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm256"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4315"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02786-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02786-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T22:52:33Z","timestamp":1646693553000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.02786-21"}},"subtitle":[],"editor":[{"given":"Nina R.","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,21]]},"references-count":80,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12,21]]}},"alternative-id":["10.1128\/mBio.02786-21"],"URL":"https:\/\/doi.org\/10.1128\/mbio.02786-21","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.22.461454","asserted-by":"object"}]},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,21]]},"assertion":[{"value":"2021-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02786-21"}}