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In this study, short-read mapping of metagenomic samples taken over time from the illeal pouch of a patient with ulcerative colitis to a\n            <jats:italic>Bacteroides fragilis<\/jats:italic>\n            metagenome-assembled genome revealed two distinct genomic arrangements of a novel conjugative transposon, CTn214, that encodes tetracycline resistance. The autonomous amplification of a plasmid-like circular form from CTn214 that includes\n            <jats:italic>tetQ<\/jats:italic>\n            potentially provides consistent ribosome protection against tetracycline. This mode of antibiotic resistance offers a novel mechanism for understanding the emergence of pathobionts like\n            <jats:italic>B. fragilis<\/jats:italic>\n            and their persistence for extended periods of time in patients with inflammatory bowel disease.\n          <\/jats:p>","DOI":"10.1128\/mbio.02787-23","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T14:01:52Z","timestamp":1706018512000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["A novel conjugative transposon carrying an autonomously amplified plasmid"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4101-1449","authenticated-orcid":true,"given":"Joseph H.","family":"Vineis","sequence":"first","affiliation":[{"name":"Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, Massachusetts, 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