{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:17:45Z","timestamp":1753881465786,"version":"3.41.2"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["225923\/Z\/22\/Z"],"award-info":[{"award-number":["225923\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2024,12,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              <jats:italic>Salmonella<\/jats:italic>\n              is a common causative agent of infectious intestinal and systemic disease and has been extensively studied for several decades. Yet, much of\n              <jats:italic>Salmonella<\/jats:italic>\n              pathogenicity remains a mystery due in part to the highly complex virulence and adaptation strategies at the pathogen\u2019s disposal. One of the more influential tools within the field, an attenuated\n              <jats:italic>aroA-<\/jats:italic>\n              deficient\n              <jats:italic>Salmonella<\/jats:italic>\n              strain, has been used for many years to probe the host immune response that would otherwise be impossible with a fully virulent strain. Now, new work by Rooke et al. (J. L. Rooke, E. C. A. Goodall, K. Pullela, R. Da Costa, et al., mBio 15:e03319-23, 2024,\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1128\/mbio.03319-23\" xlink:type=\"simple\">https:\/\/doi.org\/10.1128\/mbio.03319-23<\/jats:ext-link>\n              ) utilizes in-depth transposon-directed insertion-site sequencing to elucidate the contribution of genes to\n              <jats:italic>Salmonella<\/jats:italic>\n              fitness within isogenic wild-type and\n              <jats:italic>aroA<\/jats:italic>\n              -deficient strains. Specifically, Rooke et al. demonstrate that the deletion of the\n              <jats:italic>aroA<\/jats:italic>\n              gene leads to iron-dependent membrane instability, raising several exciting new ideas surrounding\n              <jats:italic>Salmonella<\/jats:italic>\n              biology and therapeutic strategies.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/mbio.02799-24","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T14:00:33Z","timestamp":1732197633000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["New insights on an old friend: AroA linked to iron-dependent outer membrane stability"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7500-7254","authenticated-orcid":false,"given":"Priscilla","family":"Chin","sequence":"first","affiliation":[{"name":"Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh","place":["Edinburgh, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2600-0968","authenticated-orcid":true,"given":"Christopher J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh","place":["Edinburgh, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00066-12"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81442-7"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2839-2858.2003"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.7800"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00561-4"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.22.3.763-770.1978"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252415599"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363850"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0264-410x(02)00472-3"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/291238a0"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.4161\/bbug.1.4.11243"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(91)90075-l"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00053-08"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(92)90117-7"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409239009090615"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03319-23"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.097097.109"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3033"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-022-01069-3"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01220-16"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00412-13"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00149-22"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01337.x"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-024-01613-0"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax7898"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.02799-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.02799-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T19:14:34Z","timestamp":1733944474000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.02799-24"}},"subtitle":[],"editor":[{"given":"Eduardo 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