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Biogenesis of the\n            <jats:italic>Coxiella<\/jats:italic>\n            -containing vacuole (CCV) requires effector proteins delivered into the host cell cytosol by the type 4B secretion system (T4BSS). Modifications to lysosomal physiology required for pathogen replication within the CCV are poorly understood. Mammalian (or mechanistic) target of rapamycin complex 1 (mTORC1) is a master kinase that regulates lysosome structure and function. Nutrient deprivation inhibits mTORC1, which promotes cell catabolism in the form of accelerated autophagy and increased lysosome biosynthesis. Here, we report that\n            <jats:named-content content-type=\"genus-species\">C. burnetii<\/jats:named-content>\n            growth is enhanced by T4BSS-dependent inhibition of mTORC1 that does not activate autophagy. Canonical inhibition of mTORC1 by starvation or inhibitor treatment that induces autophagic flux does not benefit\n            <jats:named-content content-type=\"genus-species\">C. burnetii<\/jats:named-content>\n            growth. Furthermore, hyperactivation of mTORC1 impairs bacterial replication. These findings indicate that\n            <jats:named-content content-type=\"genus-species\">C. burnetii<\/jats:named-content>\n            inhibition of mTORC1 without accelerated autophagy promotes bacterial growth.\n          <\/jats:p>","DOI":"10.1128\/mbio.02816-18","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T12:11:21Z","timestamp":1549282281000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Noncanonical Inhibition of mTORC1 by Coxiella burnetii Promotes Replication within a Phagolysosome-Like Vacuole"],"prefix":"10.1128","volume":"10","author":[{"given":"Charles L.","family":"Larson","sequence":"first","affiliation":[{"name":"Coxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, 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