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The bacterial second messenger c-di-GMP has been identified as a central regulator of biofilm formation, including in\n            <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n            ; however, our understanding of the pathways that contribute to this process is incomplete. Here, we define a conserved signaling system that controls the stability of large adhesion proteins at the cell surface of\n            <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n            , which are important for cell attachment and biofilm formation. Insight into the regulatory circuit underlying biofilm formation may inform targeted strategies to interfere with a process that renders this bacterium remarkably adaptable to changing environments.\n          <\/jats:p>","DOI":"10.1128\/mbio.02822-19","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T11:42:32Z","timestamp":1575286952000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae"],"prefix":"10.1128","volume":"10","author":[{"given":"Giordan","family":"Kitts","sequence":"first","affiliation":[{"name":"Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista M.","family":"Giglio","sequence":"additional","affiliation":[{"name":"Department of Molecular 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