{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:18:05Z","timestamp":1791371885269,"version":"4.3.1"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100000268","name":"UK Research and Innovation | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M028216\/1"],"award-info":[{"award-number":["BB\/M028216\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2020,2,25]]},"abstract":"<jats:p>\n                    Some serovars of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    , namely, those belonging to group D, appear to show a degree of intrinsic resistance to colistin. This observed intrinsic colistin resistance is of concern since this last-resort drug might no longer be effective for treating severe human infections with the most common\n                    <jats:italic>Salmonella<\/jats:italic>\n                    serovar,\n                    <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n                    serovar Enteritidis. Here, we show that the O-antigen epitope in group D\n                    <jats:italic>Salmonella<\/jats:italic>\n                    governs the levels of colistin susceptibility. Using whole-genome sequencing, we also revealed that increased colistin susceptibility in a group D\n                    <jats:italic>Salmonella<\/jats:italic>\n                    veterinary isolate was due to a defect in the O-antigen polymerase protein, Rfc. In summary, we show that two different mechanisms that influence the presence and composition of O antigens affect colistin susceptibility in\n                    <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n                    .\n                  <\/jats:p>","DOI":"10.1128\/mbio.02831-19","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T05:21:52Z","timestamp":1580102512000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["The O-Antigen Epitope Governs Susceptibility to Colistin in Salmonella enterica"],"prefix":"10.1128","volume":"11","author":[{"given":"Vito","family":"Ricci","sequence":"first","affiliation":[{"name":"Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Science, University of Birmingham, Birmingham, United Kingdom"},{"name":"Key Laboratory of Zoonosis of Liaoning Province, College of Animal Husbandry and Veterinary Medicine, Shenyang Agricultural University, Shenyang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Teale","sequence":"additional","affiliation":[{"name":"Animal and Plant Health Agency, Weybridge, New Haw, Addlestone, Surrey, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-473X","authenticated-orcid":false,"given":"Laura J. 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The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2014. 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Clinical laboratory testing and in vitro diagnostic test systems \u2014 Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility test devices \u2014 Part 1: Reference method for testing the in vitro activity of antimicrobial agents against rapidly growing aerobic bacteria involved in infectious diseases. International Organization for Standardization Geneva Switzerland."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2018.04.010"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6750-14-84"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-471-1_2"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-252"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)32968-0"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02831-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.02831-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T21:53:52Z","timestamp":1646690032000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.02831-19"}},"subtitle":[],"editor":[{"given":"Robert A.","family":"Bonomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,2,25]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2,25]]}},"alternative-id":["10.1128\/mBio.02831-19"],"URL":"https:\/\/doi.org\/10.1128\/mbio.02831-19","relation":{},"ISSN":["2161-2129","2150-7511"],"issn-type":[{"value":"2161-2129","type":"print"},{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,25]]},"assertion":[{"value":"2019-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02831-19"}}