{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:27:30Z","timestamp":1777274850618,"version":"3.51.4"},"reference-count":90,"publisher":"American Society for Microbiology","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["HL107380"],"award-info":[{"award-number":["HL107380"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["HL164031"],"award-info":[{"award-number":["HL164031"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"UPMC Children's Hospital of Pittsburgh"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Interferon (IFN) represents a well-known component of antiviral immunity that has been studied extensively for its mechanisms of action and therapeutic potential when antiviral treatment options are limited. Specifically in the respiratory tract, IFNs are induced directly on viral recognition to limit the spread and transmission of the virus. Recent focus has been on the IFN\u03bb family, which has become an exciting focus in recent years for its potent antiviral and anti-inflammatory activities against viruses infecting barrier sites, including the respiratory tract. However, insights into the interplay between IFN\u03bbs and other pulmonary infections are more limited and suggest a more complex role, potentially detrimental, than what was seen during viral infections. Here, we review the role of IFN\u03bbs in pulmonary infections, including viral, bacterial, fungal, and multi-pathogen super-infections, and how this may impact future work in the field.<\/jats:p>","DOI":"10.1128\/mbio.02850-22","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T17:43:51Z","timestamp":1686073431000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["IFN\u03bb: balancing the light and dark side in pulmonary infection"],"prefix":"10.1128","author":[{"given":"Danielle","family":"Antos","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA"},{"name":"Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-7711","authenticated-orcid":true,"given":"John F.","family":"Alcorn","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA"},{"name":"Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01703-09"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0421-x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni875"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni873"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2521"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140995"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102038"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12101"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.09.068"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-020-04900-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255309"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.04.025"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606413"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30566-X"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061445"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00459"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2011.07.011"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000017"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2005.04.003"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00303-10"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.10.007"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26657"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.07.007"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007420"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2016.0031"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01956-12"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69600-z"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01241-21"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00652"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a038414"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2010.05.009"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02897-14"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.12.010"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00272-10"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2018.03.003"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2915"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.3.1296"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01826.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003773"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00559-19"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33354"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.735576"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004556"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0408-z"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9061196"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa453"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.544"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00840-x"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2202370119"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/v13081602"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209760"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34709-4"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110799"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00298-15"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00015-22"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1009651"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700250"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039080"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00352-20"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003682"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.09.041"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201847556"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00374-18"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1200120"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0021OC"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900912"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.12.003"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.02.002"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3231"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02943"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20200050"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233632"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00172-11"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc2061"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc3545"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00114-19"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01939-15"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2014.0052"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.053124-0"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05120-11"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00096"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aan5357"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00321"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000067"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2105170118"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.74072"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00300"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0188-7"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002194"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00550-19"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.02850-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.02850-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T17:43:58Z","timestamp":1686073438000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.02850-22"}},"subtitle":[],"editor":[{"given":"Jacob","family":"Yount","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Emily","family":"Hemann","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":90,"alternative-id":["10.1128\/mbio.02850-22"],"URL":"https:\/\/doi.org\/10.1128\/mbio.02850-22","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]},"assertion":[{"value":"2023-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02850-22"}}