{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:18:31Z","timestamp":1773429511867,"version":"3.50.1"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/AuthorWarrantyLicense.v1"},{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100009898","name":"DOD | Defense Health Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["HHSN272201700041I\/75N93020F00001\/A38"],"award-info":[{"award-number":["HHSN272201700041I\/75N93020F00001\/A38"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"<jats:p>The rapid emergence of SARS-CoV-2 has created a global health emergency. While most human SARS-CoV-2 disease is mild, some people develop severe, life-threatening disease.<\/jats:p>","DOI":"10.1128\/mbio.02906-21","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T09:30:51Z","timestamp":1643103051000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Hamsters Expressing Human Angiotensin-Converting Enzyme 2 Develop Severe Disease following Exposure to SARS-CoV-2"],"prefix":"10.1128","volume":"13","author":[{"given":"Joseph W.","family":"Golden","sequence":"first","affiliation":[{"name":"Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis R.","family":"Cline","sequence":"additional","affiliation":[{"name":"Pathology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiankun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Pathology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4656-5379","authenticated-orcid":true,"given":"Eric M.","family":"Mucker","sequence":"additional","affiliation":[{"name":"Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amadeo J.","family":"Fuentes-Lao","sequence":"additional","affiliation":[{"name":"Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin W.","family":"Spik","sequence":"additional","affiliation":[{"name":"Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Pathology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Twenhafel","sequence":"additional","affiliation":[{"name":"Pathology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Davis","sequence":"additional","affiliation":[{"name":"Pathology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua L.","family":"Moore","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Stevens","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Blue","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aura R.","family":"Garrison","sequence":"additional","affiliation":[{"name":"Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna D.","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekah","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madelyn","family":"Kunzler","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongde","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-0415","authenticated-orcid":true,"given":"Jay W.","family":"Hooper","sequence":"additional","affiliation":[{"name":"Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200652"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa149"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008536"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.03.037"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200678"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2020.00037"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-020-00423-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14277"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02145"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2179-y"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2507"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2180-5"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00127-20"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2015.06.009"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.7.3572-3577.2004"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.142032"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001599"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa325"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009799117"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf8396"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.06.032"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01683-20"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02012-06"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2943-z"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0778-2"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.05.003"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202135"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30221-0"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010979"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6651"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02166-2"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010250"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12880"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.36740\/WLek202104144"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(20)30004-5"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10474-0"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00758-5"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.12.031"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30243-5"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.212"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.4037\/aacnacc2021302"},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","unstructured":"Gilliland T Liu Y Li R Dunn M Cottle E Terada Y Ryckman Z Alcorn M Vasilatos S Lundy J Larson D Wu H Luke T Bausch C Egland K Sullivan E Wang Z Klimstra WB. 2021. Protection of human ACE2 transgenic Syrian hamsters from SARS CoV-2 variants by human polyclonal IgG from hyper-immunized transchromosomic bovines. bioRxiv. doi:10.1101\/2021.07.26.453840.","DOI":"10.1101\/2021.07.26.453840"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2606.200516"},{"key":"e_1_3_2_49_2","volume-title":"Guide for the care and use of laboratory animals","author":"National Research Council","year":"2011","unstructured":"National Research Council. 2011. Guide for the care and use of laboratory animals, 8th ed. National Academies Press, Washington, DC.","edition":"8"},{"key":"e_1_3_2_50_2","volume-title":"Laboratory methods for histotechnology.","author":"Prophet EB","year":"1992","unstructured":"Prophet EB, Mills B, Arrington JB, Sobin LH. 1992. Laboratory methods for histotechnology. Armed Forces Institute of Pathology, Washington, DC."},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139042"}],"container-title":["mBio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.02906-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mbio.02906-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T04:04:30Z","timestamp":1646712270000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.02906-21"}},"subtitle":[],"editor":[{"given":"Himanshu","family":"Batra","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Marthandan","family":"Mahalingam","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,22]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2,22]]}},"alternative-id":["10.1128\/mbio.02906-21"],"URL":"https:\/\/doi.org\/10.1128\/mbio.02906-21","relation":{},"ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,22]]},"assertion":[{"value":"2021-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02906-21"}}