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In most studied organisms, AP-2 is involved in bringing material into the cell from outside, a process called endocytosis. Previous work shows that changes to the \u03bc subunit of AP-2 can contribute to drug resistance. Our experiments show that AP-2 is essential for parasite development in blood but does not have any role in clathrin-mediated endocytosis. This suggests that a specialized function for AP-2 has developed in malaria parasites, and this may be important for understanding its impact on drug resistance.\n                  <\/jats:p>","DOI":"10.1128\/mbio.02918-19","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T07:03:45Z","timestamp":1582527825000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["The\n                    <i>Plasmodium falciparum<\/i>\n                    Artemisinin Susceptibility-Associated AP-2 Adaptin \u03bc Subunit is Clathrin Independent and Essential for Schizont Maturation"],"prefix":"10.1128","volume":"11","author":[{"given":"Ryan C.","family":"Henrici","sequence":"first","affiliation":[{"name":"Department of Infection Biology, Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United 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