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Gonococcal infection of the human cervix is initiated by an interaction between a galactose modification made to its surface appendages, pili, and the I-domain region of (host) complement receptor 3 (CR3). By targeting this crucial gonococcal\u2013I-domain interaction, it may be possible to prevent cervical infection in females. To this end, we identified the I-domain galactose-binding epitope of CR3 and characterized its galactose lectin activity. Moreover, we identified two drugs, carbamazepine and methyldopa, as effective host-targeted therapies for gonorrhea treatment. At doses below those currently used for their respective existing indications, both carbamazepine and methyldopa were more effective than ceftriaxone in curing cervical infection\n                    <jats:italic>ex vivo<\/jats:italic>\n                    . This host-targeted approach would not be subject to\n                    <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n                    drug resistance mechanisms. Thus, our data suggest a long-term solution to the growing problem of multidrug-resistant\n                    <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n                    infections.\n                  <\/jats:p>","DOI":"10.1128\/mbio.03046-19","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T05:09:31Z","timestamp":1582952971000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Repurposed Drugs That Block the Gonococcus-Complement Receptor 3 Interaction Can Prevent and Cure Gonococcal Infection of Primary Human Cervical Epithelial Cells"],"prefix":"10.1128","volume":"11","author":[{"given":"Jessica","family":"Poole","sequence":"first","affiliation":[{"name":"Institute for Glycomics, Griffith University, Southport, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Day","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Southport, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Haselhorst","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Southport, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freda E.-C.","family":"Jen","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Southport, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor J.","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Microbiology, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Edwards","sequence":"additional","affiliation":[{"name":"The Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital and The Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Jennings","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Southport, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00010-14"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000154501.22566.fa"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0091-7435(02)00058-0"},{"key":"e_1_3_3_5_2","first-page":"627","volume-title":"Sexually transmitted diseases.","author":"Hook EW","year":"2008","unstructured":"Hook EW, Hansfield HH. 2008. 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